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Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (75 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Gpcr complex of succinate receptor (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Gpcr complex (Complex from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9a
Q-score: 0.591
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.007 Pubmed: 38582077 ]
- Water (18 Da, Ligand)
- Human pi3k-alpha (p85/p110-h1047r) with qr-7909 binding at an allosteric site (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- 6-chloranyl-3-[[(1r)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid (490 Da, Ligand)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w9b
Q-score: 0.496
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) [ DOI: doi:10.1016/j.str.2024.03.007 Pubmed: 38582077 ]
- Human pi3k-alpha (p85/p110-h1047r) with qr-8557 binding at an allosteric site (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (33 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- 1-[(1s)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea (395 Da, Ligand)
